Product Name	IL3RA
Chinese Name	白介素3受体a（CD123）链抗体
Alias	Interleukin-3 receptor subunit alpha; IL-3R alpha; Interleukin-3 receptor subunit alpha precursor; CD 123; CD123; CD123 antigen; hIL3Ra; IL 3 receptor subunit alpha; IL 3R alpha; IL 3R; IL 3R subunit alpha; IL3 receptor subunit alpha; IL3R alpha; IL3R; IL3RAY; IL3RX; IL3RY; Interleukin 3 receptor alpha; Interleukin 3 receptor, alpha (low affinity); Interleukin-3 receptor; MGC34174; IL3RA_HUMAN; IL-3Rα.   Interleukin-3 receptor subunit alpha
Research Area	Cell biology  immunology  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Detection molecular weight	70 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-3R alpha: 201-300/378 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012] Function: This is a receptor for interleukin-3. Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily. SWISS: P26951 Gene ID: 3563 Database links: Entrez Gene: 3563 Human Omim: 308385 Human Omim: 430000 Human SwissProt: P26951 Human Unigene: 632790 Human 白细胞介素3受体α(IL-3Rα)又称CD123，是造血生长因子受体家族成员,CD123是未分化白血病Stem cells的特异标志.在细胞Signal transduction、Apoptosis及血液Tumour发生中起重要作用.
Product Picture	Tissue/cell: mouse lymphoma tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL3R alpha Polyclonal Antibody, Unconjugated(SL2600R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Blank control(blue): U937(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-IL3R antibody(SL2600R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG (orange) ,used under the same conditions. Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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