Product Name	CD226
Chinese Name	CD226抗体
Alias	DNAX accessory molecule 1; adhesion glycoprotein; CD226 antigen; DNAM1; platelet and T cell activation antigen 1; PTA1; TLiSA1; CD226; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; T lineage specific activation antigen 1 antigen.
literatures	Specific References  (1)     |     SL2569R has been referenced in 1 publications. [IF=15.304] Yao Lei. et al. Phytochemical natural killer cells reprogram tumor microenvironment for potent immunotherapy of solid tumors. BIOMATERIALS. 2022 Jun;:121635  WB, IF, FC ;  Mouse.   PubMed:10.1016/j.biomaterials.2022.121635
Research Area	immunology  Cell adhesion molecule  Cell Surface Molecule  Cell type markers  Natural killer cells  lymphocyte  t-lymphocyte  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	35kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD226: 201-300/336 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008] Subunit: Interacts with PVR and PVRL2. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed by peripheral blood T-lymphocytes. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SWISS: Q15762 Gene ID: 10666 Database links: Entrez Gene: 10666 Human Omim: 605397 Human SwissProt: Q15762 Human Unigene: 660130 Human CD226分子是一种广泛表达于多种免疫The cell membrane表面的Ⅰ型跨膜glycoprotein，CD226广泛表达于T细胞、NK细胞、NK T细胞、活化的vascular endothelial cell、巨核/血小板谱系、单核细胞、胸腺细胞、某些B细胞亚群、部分造血Stem cells和肥大细胞等免疫细胞表面，在免疫系统以外则分布于海马和小脑皮质的神经突触部位。CD226与其配体的相互作用参与CTL和NK细胞的活化、分化和细胞毒作用,调节CD4+ T细胞的增殖和分化，介导endothelial cells与其他细胞的黏附,促进血小板的活化与聚集，参与造血调控，介导肥大细胞的脱颗粒作用，参与NK T细胞和胸腺细胞的抗凋亡作用、树突状细胞的成熟、免疫突触和神经突触的形成，并与Tumour、自身免疫性疾病、移植排斥及病毒感染等疾病密切相关。
Product Picture	Sample: Jurkat(Human) Cell Lysate at 30 ug Primary: Anti-CD226 (SL2569R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 35 kD Observed band size: 35 kD Blank control(blue): Jurkat cells(fixed with 2% paraformaldehyde (10 min) ). Primary Antibody:Rabbit Anti-CD226 antibody(SL2569R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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