Product Name	CD11c
Chinese Name	整合素αX抗体
Alias	Integrin alpha-X; integrin alpha-X precursor; ITGAX; SLEB6; CD11C (p150) alpha polypeptide; complement receptor 4; integrin aX; CD11 antigen-like family member C; leukocyte adhesion receptor p150,95; leukocyte adhesion glycoprotein p150,95 alpha chain; ITAX_HUMAN.
literatures	Specific References  (14)     |     SL2508R has been referenced in 14 publications. [IF=15.304] Jinbo Li. et al. Autophagy inhibition recovers deficient ICD-based cancer immunotherapy. BIOMATERIALS. 2022 Aug;287:121651  IF ;  Mouse.   PubMed:35777331 [IF=10.435] Wan, Guoyun. et al. Gene augmented nuclear-targeting sonodynamic therapy via Nrf2 pathway-based redox balance adjustment boosts peptide-based anti-PD-L1 therapy on colorectal cancer. J Nanobiotechnol. 2021 Dec;19(1):1-26  IF ;  Mouse.   PubMed:34715867 [IF=7.727] Jinbo Li. et al. Low dose shikonin and anthracyclines coloaded liposomes induce robust immunogenetic cell death for synergistic chemo-immunotherapy. J Control Release. 2021 Jul;335:306  IHC ;  Mouse.   PubMed:34081995 [IF=7.577] Wei C et al. Nanocolloids in drinking water increase the risk of obesity in mice by modulating gut microbesEnviron Int.2021 Jan;146:106302.  IHC ;  Mouse.   PubMed:33395945 [IF=7.27] Zhang, Xinwen, et al. "Peripheral Role of Cathepsin S in Th1 Cell-Dependent Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State." The Journal of Neuroscience 34.8 (2014): 3013-3022.  Rat.   PubMed:24553941 [IF=5.085] Xianmei Liu. et al. Tropomodulin1 Expression Increases Upon Maturation in Dendritic Cells and Promotes Their Maturation and Immune Functions. Front Immunol. 2020; 11: 587441  WB,FC ;  Mouse.   PubMed:33552047 [IF=4.92] Ahn, Jeonghyun, Phillip Ruiz, and Glen N. Barber. "Intrinsic self-DNA triggers inflammatory disease dependent on STING." The Journal of Immunology 193.9 (2014): 4634-4642.  IHC-P ;  Mouse.   PubMed:25261479 [IF=4.657] He, Xiaojing. et al. Inhibition of PD-1 Alters the SHP1/2-PI3K/Akt Axis to Decrease M1 Polarization of Alveolar Macrophages in Lung Ischemia–Reperfusion Injury. INFLAMMATION. 2022 Nov;:1-16  IHC ;  Rat.   PubMed:36357527 [IF=4.225] Zhao B et al. A TCM Formula YYWY Inhibits Tumor Growth in Non-Small Cell Lung Cancer and Enhances Immune-Response Through Facilitating the Maturation of Dendritic Cells. Front Pharmacol. 2020 Jun 9;11:798.  IHF-P ;  Mouse.   PubMed:32595493 [IF=3.88] Di Filippo, C., et al. "Involvement of Proteasome and Macrophages M2 in the Protection Afforded by Telmisartan against the Acute Myocardial Infarction in Zucker Diabetic Fatty Rats with Metabolic Syndrome." Mediators of Inflammation 2014 (2014).  IHC-P ;  Rat.   PubMed:25110402 [IF=3.816] Hao X et al. Establishing a Multicolor Flow Cytometry to Characterize Cellular Immune Response in Chickens Following H7N9 Avian Influenza Virus InfectionViruses.2020 Dec 6;12(12):1396.  FCM ;  Chicken.   PubMed:33291218 [IF=2.485] Ju et al. An effective cytokine adjuvant vaccine induces autologous T-cell response against colon cancer in an animal model. (2016) BMC.Immunol. 17:31  IHC ;  Mouse.   PubMed:27669687 [IF=1.26] Liao et al. Bone mesenchymal stem cells co-expressing VEGF and BMP-6 genes to combat avascular necrosis of the femoral head. (2018) Exp.Ther.Med. 15:954-962  FCM ;  Rat.   PubMed:29399103 [IF=0] Rossi et al. Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. (2016) Mediators.Inflam. 2016:7368389  WB ;  Mouse.   PubMed:26949291
Research Area	Cell biology  immunology  Signal transduction  Stem cells  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, )
Applications	ELISA=1:5000-10000 Flow-Cyt=1μg/Test IF=1:200-800  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	126kDa
Detection molecular weight	145-150 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Integrin Alpha X: 501-600/1163
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. [provided by RefSeq]. Function: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Subcellular Location: Membrane. Tissue Specificity: Predominantly expressed in monocytes and granulocytes. Similarity: Belongs to the integrin alpha chain family. Contains 7 FG-GAP repeats. Contains 1 VWFA domain. SWISS: P20702 Gene ID: 3687 Database links: Entrez Gene: 3687 Human Entrez Gene: 16411 Mouse Entrez Gene: 499271 Rat Omim: 151510 Human SwissProt: P20702 Human SwissProt: Q9QXH4 Mouse Unigene: 248472 Human Unigene: 22378 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD11c) Polyclonal Antibody, Unconjugated (SL2508R) at 1:400 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (SL0295G-FITC) for 90 minutes, and DAPI for nuclei staining. Blank control: Raw264.7. Primary Antibody (green line): Rabbit Anti-CD11c antibody (SL2508R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-AF647 Dilution: 1μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. Blank control: Raw264.7. Primary Antibody (green line): Rabbit Anti-CD11c antibody (SL2508R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-AF647 Dilution: 1μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. Blank control (blue): U937 cells(fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-CD11c antibody(SL2508R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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