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Product Name CD23 Chinese Name CD23/FcεRII抗体 Alias Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragment of IgE low affinity II receptor for; Fc fragment of IgE, low affinity II, receptor for (CD23); Fc of IgE, low affinity II, receptor for (CD23); Fc receptor IgE low affinity II alpha polypeptide; Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a; FCE 2; FCE2; FCER 2; FCER2; FCER2A; IgE binding factor; IgE receptor lymphocyte; IgE-binding factor; IGEBF; Immunoglobulin E binding factor; Immunoglobulin E receptor, low affinity II; Low affinity immunoglobulin epsilon Fc receptor; Low affinity immunoglobulin epsilon Fc receptor membrane bound form; Low affinity immunoglobulin epsilon Fc receptor soluble form; Ly-42; Ly42; Lymphocyte antigen CD23; Lymphocyte IgE receptor; MGC93219. Research Area Cell biology immunology Stem cells Cell type markers lymphocyte t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 36kDa Cellular localization The cell membrane Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CD23: 221-321/321 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Function:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form.
Post-translational modifications:
N- and O-glycosylated.
Similarity:
Contains 1 C-type lectin domain.
SWISS:
P06734
Gene ID:
2208
Database links:Entrez Gene: 2208 Human
Entrez Gene: 14128 Mouse
Omim: 151445 Human
SwissProt: P06734 Human
SwissProt: P20693 Mouse
Unigene: 465778 Human
Unigene: 1233 Mouse
CD23是一种II型跨膜glycoprotein,是存在于B细胞表面的IgE受体。在慢性Blymphocyte白血病(CLL)和小B细胞淋巴瘤(SLL)为阳性,套细胞淋巴瘤和小核裂lymphocyte淋巴瘤阴性。也表达于外周血B细胞的某些亚型、Blymphocyte和EB病毒转染的B淋巴瘤细胞系。CD23是慢性Blymphocyte白血病,小B细胞淋巴瘤诊断和鉴别诊断有用的标记物。Product Picture Sample:
293T Cell (Human) Lysate at 30 ug
Primary: Anti- CD23 (SL2490R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 50/40 kD
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