Product Name	TAP2
Chinese Name	ATP结合转运因子2抗体
Alias	ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; RING 11; TAP 2; Transporter 2 ATP binding cassette sub family B.
literatures	Specific References  (1)     |     SL2374R has been referenced in 1 publications. [IF=17.694] Lei, Xin. et al. CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment. NAT COMMUN. 2023 Jan;14(1):1-14  FCM ;  Human.   PubMed:36639382
Research Area	Tumour  Cell biology  immunology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 Flow-Cyt=1μg/Test  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	75kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TAP2: 451-550/686
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. Subunit: Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. SWISS: C9J069 Gene ID: 6891 Database links: Entrez Gene: 6891?/span>Human Omim: 170261?/span>Human SwissProt: Q03519?/span>Human Unigene: 502?/span>Human
Product Picture	Tissue/cell: Human endometrium carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TAP2/ABCB3 Polyclonal Antibody, Unconjugated(SL2374R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Fixed and permeabilized EL-4 cells were labeled with Rabbit Anti- TAP2/ABCB3 Polyclonal Antibody, Unconjugated (SL2374R) at 1:200 followed by conjugation to the secondary antibody Goat Anti-Rabbit IgG FITC conjugated Secondary Antibody at 1:200 dilution.

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