Product Name	Involucrin
Chinese Name	囊包蛋白/内披蛋白抗体
Alias	INVO_MOUSE; involucrin; ivl.
Research Area	Cell biology  Signal transduction  Cyclin  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	64kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Involucrin: 21-120/467
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]. Function: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Subunit: Directly or indirectly cross-linked to cornifelin (CNFN). Subcellular Location: Cytoplasm. Tissue Specificity: Keratinocytes of epidermis and other stratified squamous epithelia. Post-translational modifications: Substrate of transglutaminase. Some glutamines and lysines are cross-linked to other involucrin molecules, to other proteins such as keratin, desmoplakin, periplakin and envoplakin, and to lipids like omega-hydroxyceramide. Similarity: Belongs to the involucrin family. SWISS: P07476 Gene ID: 16447 Database links: Entrez Gene: 3713 Human Entrez Gene: 16447 Mouse Entrez Gene: 60583 Rat Omim: 147360 Human SwissProt: P07476 Human SwissProt: P48997 Mouse SwissProt: P48998 Rat Unigene: 516439 Human Unigene: 207365 Mouse Unigene: 142591 Rat 套膜蛋白又称内披蛋白或囊包蛋白，与毛透明蛋白共同构成角质细胞包膜支架的蛋白质。在角质Cell differentiation时，首先出现在表皮棘层的上层细胞中的标志性蛋白质，该蛋白在角质细胞和其他复层扁平上皮合成的蛋白。最初存在于细胞质中，然后通过转谷氨酰胺酶的作用，转变为交联的膜蛋白。
Product Picture	Sample: MCM-7(Human) Cell Lysate at 30 ug Primary: Anti-Involucrin (SL23062R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 64 kD Observed band size: 64 kD

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