Product Name	Pescadillo
Chinese Name	Pescadillo抗体
Alias	FLJ43790; Homo sapiens pescadillo mRNA complete cds; PES 1; PES; pes1; PESC_HUMAN; Pescadillo (zebrafish) homolog 1 containing BRCT domain; Pescadillo homolog 1; Pescadillo homolog 1 containing BRCT domain (zebrafish); Pescadillo homolog; Pescadillo ribosomal biogenesis factor 1.
Research Area	Tumour  Cell biology  immunology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Pescadillo: 21-120/588
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pescadillo may play a crucial role in cell proliferation and may be necessary for oncogenic transformation and tumor progression. The protein is abnormally elevated in malignant tumors of astrocytic origin. It is a strongly conserved gene containing a BRCT domain that is essential for the activity of this gene product. Function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Subunit: Interacts with IRS1 and UBTF. May interact with MAP1B (By similarity). Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Subcellular Location: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. Tissue Specificity: Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin. Post-translational modifications: Sumoylated. Similarity: Belongs to the pescadillo family. Contains 1 BRCT domain. SWISS: O00541 Gene ID: 23481 Database links: Entrez Gene: 23481 Human Entrez Gene: 64934 Mouse Entrez Gene: 289740 Rat Omim: 605819 Human SwissProt: O00541 Human SwissProt: Q5SQ20 Mouse SwissProt: Q9EQ61 Mouse SwissProt: Q3B8N8 Rat Unigene: 517543 Human Unigene: 28659 Mouse Unigene: 9521 Rat
Product Picture	Sample: Hela(human)cell Lysate at 40 ug Primary: Anti-Pescadillo(SL20263R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 68kD Observed band size: 63kD

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