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Product Name SLC25A25 Chinese Name 溶质载体家族蛋白25成员A25抗体 Alias Calcium-binding mitochondrial carrier protein SCaMC-2; KIAA1896; MCSC; MGC105138; MGC119514; MGC119515; MGC119516; MGC119517; Mitochondrial ATP Mg/Pi carrier; Mitochondrial ATP-Mg/Pi carrier protein 3; Mitochondrial Ca(2+)-dependent solute carrier protein 3; Mitochondrial Ca2+ dependent solute carrier; Mitochondrial calcium-dependent solute carrier; PCSCL; RP11 395P17.4; SCAMC 2; SCAMC2; SCMC2_HUMAN; Short calcium binding mitochondrial carrier 2; SLC25A25; Small calcium binding mitochondrial carrier 2; Small calcium-binding mitochondrial carrier protein 2; Solute carrier family 25 (mitochondrial carrier phosphate carrier) member 25; Solute carrier family 25 member 25; solute carrier family 25, member 25, isoform a. Research Area Tumour Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Guinea Pig, Cat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 52kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SLC25A25: 1-100/469 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]
Function:
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.
Subcellular Location:
Mitochondrion inner membrane.
Tissue Specificity:
Present in various cell lines (at protein level). Widely expressed. Expressed in fetal and adult liver, skeletal muscle, testis, ovary, hippocampus and caudate nucleus. Isoform 1 is present in all tissues tested. Isoform 2 expression is restricted to kidney and lung.
Similarity:
Belongs to the mitochondrial carrier family.
Contains 3 EF-hand domains.
Contains 3 Solcar repeats.
SWISS:
Q6KCM7
Gene ID:
114789
Database links:
Entrez Gene: 114789 Human
Entrez Gene: 227731 Mouse
Entrez Gene: 406541 Zebrafish
Omim: 608745 Human
SwissProt: Q6KCM7 Human
SwissProt: A2ASZ8 Mouse
SwissProt: A2CEQ0 Zebrafish
Unigene: 5476 Human
Unigene: 37395 Mouse
Unigene: 473265 Mouse
Unigene: 17644 Rat
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