TEL: +86 571 56623320 EMAIL: [email protected]
Product Name RBM35A/ESRP1 Chinese Name RNABinding protein35A抗体 Alias Epithelial splicing regulatory protein 1; Esrp1; ESRP1_HUMAN; FLJ20171; RBM35A; RMB35A; RNA binding motif protein 35A; RNA-binding motif protein 35A; RNA-binding protein 35A. Research Area Binding protein Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Rabbit, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 76kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RBM35A: 151-250/681 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Subcellular Location:
Nucleus.
Tissue Specificity:
Epithelial cell-specific.
Similarity:
Belongs to the ESRP family.
Contains 3 RRM (RNA recognition motif) domains.
SWISS:
Q6NXG1
Gene ID:
54845
Database links:
Entrez Gene: 100055214 Horse
Entrez Gene: 54845 Human
Entrez Gene: 207920 Mouse
Omim: 612959 Human
SwissProt: Q6NXG1 Human
SwissProt: Q3US41 Mouse
Unigene: 487471 Human
Unigene: 387719 Mouse
Unigene: 161971 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (Rat colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RBM35A) Polyclonal Antibody, Unconjugated (SL19771R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
Scan Wechat Qrcode