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Product Name SEC61A Chinese Name TransporterSEC61A抗体 Alias chunp6898; fb62c11; HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; Protein transport protein Sec61 subunit alpha isoform 1; S61A1_HUMAN; SEC 61; SEC 61A; Sec61 alpha 1; Sec61 alpha 1 subunit; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha-1; SEC61; Sec61 homolog; SEC61A1; sec61aa. Research Area Cell biology Signal transduction Transporter Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Dog, Cow, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 52kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SEC61A: 181-280/476 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Function:
Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins.
Subunit:
Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the secY/SEC61-alpha family.
SWISS:
P61619
Gene ID:
29927
Database links:Entrez Gene: 29927 Human
Entrez Gene: 53421 Mouse
Entrez Gene: 192298 Zebrafish
Omim: 609213 Human
SwissProt: P61619 Human
SwissProt: P61620 Mouse
SwissProt: Q90ZM2 Zebrafish
Unigene: 518236 Human
Unigene: 28375 Mouse
Unigene: 485032 Mouse
Unigene: 47029 Rat
Unigene: 51503 Zebrafish
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