Product Name	PTGEs/Prostaglandin E Synthase
Chinese Name	前列腺素E合成酶抗体
Alias	Glutathione S transferase 1 like 1; MGC10317; MGST IV; MGST1 L1; MGST1 like 1; MGST1-L1; MGST1L1; MGSTIV; Microsomal glutathione S transferase 1 like 1; Microsomal glutathione S-transferase 1-like 1; Microsomal prostaglandin E synthase 1; Microsomal prostaglandin E synthase 1; mPGES 1; MPGES; mPGES-1; p53 induced apoptosis protein 12; p53 induced gene 12; p53 induced gene 12 protein; p53-induced gene 12 protein; PGES; PIG 12; PIG12; PP 102; PP 1294; PP102; PP1294; Prostaglandin E synthase; PTGES; PTGES_HUMAN; TP53I12; Tumor protein p53 inducible protein 12.
literatures	Specific References  (1)     |     SL1880R has been referenced in 1 publications. [IF=25.606] Zhou, Lei. et al. Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nat Immunol. 2022 Jan;23(2):251-261  FC ;  Human.   PubMed:35102343
Research Area	Tumour  Cell biology  immunology  Apoptosis  Kinases and Phosphatases  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	17kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PTGEs: 85-152/152
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Prostaglandin E synthase catalyses conversion of COX derived PGH2 to PGE2. It is a member of the MAPEG family. It may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain during inflammatory responses. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. Function: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Subunit: Homotrimer. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the MAPEG family. SWISS: O14684 Gene ID: 9536 Database links: Entrez Gene: 417193 Chicken Entrez Gene: 282019 Cow Entrez Gene: 480698 Dog Entrez Gene: 9536 Human Entrez Gene: 64292 Mouse Entrez Gene: 59103 Rat Entrez Gene: 544666 Zebrafish Omim: 605172 Human SwissProt: O14684 Human SwissProt: Q9JM51 Mouse Unigene: 146688 Human Unigene: 28768 Mouse Unigene: 7730 Rat PTGES由白介素-1β诱导产生，可能参与P53诱导的凋亡过程。
Product Picture	Sample: Jurkat(Human) Cell Lysate at 30 ug Primary: Anti-PTGEs (SL1880R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 17 kD Observed band size: 18 kD

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