Product Name	MPI/Mannose Phosphate Isomerase
Chinese Name	磷酸甘露糖异构酶抗体
Alias	PMI1; CDG1B; FLJ39201; Mannose 6 phosphate isomerase; Mannose-6-phosphate isomerase; MANNOSEPHOSPHATE ISOMERASE; MGC94106; MPI; MPI_HUMAN; Phosphohexomutase; phosphomannose isomerase 1; Phosphomannose isomerase; PMI.
literatures	Specific References  (1)     |     SL18654R has been referenced in 1 publications. [IF=2.886] Jun Sha. et al. Mannose Impairs Lung Adenocarcinoma Growth and Enhances the Sensitivity of A549 Cells to Carboplatin. Cancer Manag Res. 2020; 12: 11077–11083  IHC ;  Human.   PubMed:33173340
Research Area	Tumour  Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	46kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MPI/Mannose Phosphate Isomerase: 61-160/423
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] Function: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in all tissues, but more abundant in heart, brain and skeletal muscle. DISEASE: Defects in MPI are the cause of congenital disorder of glycosylation type 1B (CDG1B) [MIM:602579]; also known as carbohydrate-deficient glycoprotein syndrome type Ib (CDGS1B). Congenital disorders of glycosylation are metabolic deficiencies in glycoprotein biosynthesis that usually cause severe mental and psychomotor retardation. They are characterized by under-glycosylated serum glycoproteins. CDG1B is clinically characterized by protein-losing enteropathy. Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family. SWISS: P34949 Gene ID: 4351 Database links: Entrez Gene: 4351 Human Entrez Gene: 513586 Cow Entrez Gene: 110119 Mouse Entrez Gene: 300741 Rat Omim: 154550 Human SwissProt: Q3SZI0 Cow SwissProt: P34949 Human SwissProt: Q924M7 Mouse SwissProt: Q68FX1 Rat Unigene: 75694 Human Unigene: 247218 Mouse Unigene: 44246 Rat

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