Rabbit Anti-LIN9 antibody
BARA; Beta subunit-associated regulator of apoptosis; Beta-subunit associated regulator of apoptosis; hLin-9; huLin-9; lin-9; lin9; LIN9_HUMAN; pRB-associated protein; Protein lin-9 homolog; TGS; TUDOR gene similar protein; Type I interferon receptor beta
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Product Name LIN9 Chinese Name LIN9蛋白抗体 Alias BARA; Beta subunit-associated regulator of apoptosis; Beta-subunit associated regulator of apoptosis; hLin-9; huLin-9; lin-9; lin9; LIN9_HUMAN; pRB-associated protein; Protein lin-9 homolog; TGS; TUDOR gene similar protein; Type I interferon receptor beta chain-associated protein. Research Area Cell biology Apoptosis Cyclin Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 62kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LIN9 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Function:
Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition.
Subcellular Location:
Nucleus > nucleoplasm. Found in perinucleolar structures. Associated with chromatin.
Tissue Specificity:
Expressed in thymus and testis.
Similarity:
Belongs to the lin-9 family.
SWISS:
Q5TKA1
Gene ID:
286826
Database links:Entrez Gene: 286826 Human
Entrez Gene: 421316 Chicken
Entrez Gene: 72568 Mouse
Entrez Gene: 323027 Zebrafish
Entrez Gene: 560867 Zebrafish
Omim: 609375 Human
SwissProt: Q5TKA1 Human
SwissProt: Q8C735 Mouse
SwissProt: Q5RHQ8 Zebrafish
Unigene: 120817 Human
Unigene: 275044 Mouse
Unigene: 214693 Rat
Unigene: 76676 Zebrafish
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Sample:
Bone (Mouse) Lysate at 40 ug
Primary: Anti-LIN9 (SL18283R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 62 kD
Observed band size: 62 kD
Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-LIN9 Polyclonal Antibody, Unconjugated(SL18283R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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