Product Name	Monoamine oxidase A+B
Chinese Name	单氨氧化酶A+B抗体
Alias	Adrenalin oxidase; AOFA_HUMAN; AOFB_HUMAN; Amine oxidase (flavin containing) A; Amine oxidase (flavin containing); Amine oxidase (flavin containing) B; Brunner syndrome; MAO A; MAO; MAO brain; MAO platelet; MAOA; MAOB; Monoamine oxidase A; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase type A; Monoamine oxidase type B; Tyramine oxidase.
literatures	Specific References  (1)     |     SL11890R has been referenced in 1 publications. [IF=6.208] Subramaniam Jayanthi. et al. Biochemical Neuroadaptations in the Rat Striatal Dopaminergic System after Prolonged Exposure to Methamphetamine Self-Administration. INT J MOL SCI. 2022 Jan;23(17):10092  WB ;  Rat.   PubMed:36077488
Research Area	Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	60+59kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Monoamine oxidase A+B: 131-230/527
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Monoamine oxidase A and B catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. MAOB preferentially degrades benzylamine and phenylethylamine Function: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Subunit: Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer. Subcellular Location: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Tissue Specificity: Heart, liver, duodenum, blood vessels and kidney. DISEASE: Defects in MAOA are the cause of Brunner syndrome (BRUNS) [MIM:300615]. Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Similarity: Belongs to the flavin monoamine oxidase family. SWISS: P21397 P27338 Gene ID: 4128 4129 Database links: UniProtKB/Swiss-Prot: P21397.1 UniProtKB/Swiss-Prot: P27338.3
Product Picture	Blank control: Hela. Primary Antibody (green line): Rabbit Anti-Monoamine oxidase A+B antibody (SL11890R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 20% PBST for 20 min atroom temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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