Product Name	Frizzled 9
Chinese Name	CD349抗体
Alias	CD 349; CD 349 antigen; CD349; Frizzled Drosophila homolog of 3 Frizzled homolog 9 (Drosophila); Frizzled homolog 9; Frizzled-9; Fz 9; Fz-9; FZD 3; Fzd 9; FZD3; FZD3-PEN; Fzd9; FZD9_HUMAN; FzE6; hFz9; ymfz9; Xfz9.
literatures	Specific References  (1)     |     SL11842R has been referenced in 1 publications. [IF=1] Vasyliev, R. G., et al. "Large-scale expansion and characterization of human adult neural crest-derived multipotent stem cells from hair follicle for regenerative medicine applications." Experimental Oncology 39.3 (2017): 171-180.  FCM ;  Human.   PubMed:28967641
Research Area	Cell biology  Neurobiology  Signal transduction  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 ICC=1:100-500 IF=1:100-500  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Frizzled 9/CD349: 185-270/591 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008] Function: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Subcellular Location: Cell membrane. Tissue Specificity: Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Post-translational modifications: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome Similarity: Belongs to the G-protein coupled receptor Fz/Smo family. Contains 1 FZ (frizzled) domain. SWISS: O00144 Gene ID: 8326 Database links: Entrez Gene: 8326 Human Entrez Gene: 14371 Mouse Entrez Gene: 266608 Rat Omim: 601766 Human SwissProt: O00144 Human SwissProt: Q9R216 Mouse Unigene: 647029 Human Unigene: 6256 Mouse
Product Picture	Sample: Lane 1: Human SH-SY5Y cell lysates Lane 2: Human MCF-7 cell lysates Primary: Anti- Frizzled 9 (SL11842R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 62 kDa Observed band size: 64 kDa

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