Product Name	IL17A
Chinese Name	白介素-17抗体
Alias	Interleukin-17A; CTLA-8; CTLA 8; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL-17A; IL-17; Interleukin 17; Interleukin-17; Interleukin 17A; Interleukin17; Interleukin17A; IL17_HUMAN; IL17_MOUSE.
literatures	Specific References  (33)     |     SL1183R has been referenced in 33 publications. [IF=24.897] Yuan, Xulei. et al. Systemic antibiotics increase microbiota pathogenicity and oral bone loss. INT J ORAL SCI. 2023 Jan;15(1):1-14  IHC ;  Mouse.   PubMed:36631439 [IF=8.786] Xiaoyu Guo. et al. Effects of Boric Acid Gel on Vaginal Candida albicans Infections and the Local Immune System in Mice. FRONT IMMUNOL. 2022; 13: 950215  IHC ;  Mouse.   PubMed:35958550 [IF=7.324] Yongbo Kang. et al. A Novel Synbiotic Alleviates Autoimmune Hepatitis by Modulating the Gut Microbiota-Liver Axis and Inhibiting the Hepatic TLR4/NF-κB/NLRP3 Signaling Pathway. MSYSTEMS. 2023 Feb 16  IHC ;  Mouse.   PubMed:36794950 [IF=7] L.H. Frommherz. et al. Secukinumab for the treatment of SAM syndrome associated with desmoglein‐1 deficiency. 2020 Nov 18  IHC ;  Human.   PubMed:33205394 [IF=6.575] Qingqing Liu. et al. A Synbiotic Ameliorates Con A-Induced Autoimmune Hepatitis in Mice Through Modulation of Gut Microbiota And Immune Imbalance. MOL NUTR FOOD RES. 2023 Jan;:2200428  IF,IHC ;  Mouse.   PubMed:36708241 [IF=6.575] Prema Robinson. et al. Therapeutic Potential of a Small-Molecule STAT3 Inhibitor in a Mouse Model of Colitis. CANCERS. 2023 Jan;15(11):2977  IHC ;  Mouse.   PubMed:37296943 [IF=6.048] Qingqing Liu. et al. Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability. J Nutr Biochem. 2021 Sep;:108863  IHC ;  mouse.   PubMed:34517094 [IF=5.714] Mingwei Tong. et al. The Trichinella spiralis-derived antigens alleviate HFD-induced obesity and inflammation in mice. INT IMMUNOPHARMACOL. 2023 Apr;117:109924  IHC ;  Mouse.   PubMed:36848791 [IF=5.396] Tin-Yun Ho. et al. Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition on interleukin-17A/interleukin-17A receptor interaction. FOOD FUNCT. 2022 May;:  IHC ;  Mouse.   PubMed:35674182 [IF=5.279] Yan Zhang. et al. Ganoderic Acid A To Alleviate Neuroinflammation of Alzheimer’s Disease in Mice by Regulating the Imbalance of the Th17/Tregs Axis. J Agr Food Chem. 2021;69(47):14204–14214  WB ;  Mouse.   PubMed:34798773 [IF=5.195] Feng Huang. et al. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. J ETHNOPHARMACOL. 2023 Jan;300:115626  IHC ;  Mouse.   PubMed:10.1016/j.jep.2022.115626 [IF=5.195] Huangguan Qin. et al. Toddalia asiatica extract attenuates adjuvant-induced arthritis by modulating colon Th17/Treg balance and colony homeostasis. J ETHNOPHARMACOL. 2023 Apr;:116542  WB ;  Rat.   PubMed:37127142 [IF=4.964] Prema Robinson. et al. Genetic and Small-Molecule Modulation of Stat3 in a Mouse Model of Crohn’s Disease. J CLIN MED. 2022 Jan;11(23):7020  IHC ;  Mouse.   PubMed:36498596 [IF=4.36] An Wang. et al. Yiqi Jiedu herbal decoction attenuates the 2 Gy 60Co γ ray induced spleen injury by inhibiting apoptosis and modulating the immune balance. J Ethnopharmacol. 2022 Mar;286:114925  IHC ;  Mouse.   PubMed:34933086 [IF=4.03] Venkatasubramanian, Sambasivan, et al. "Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection." European Journal of Immunology (2015).  IHC-P ;  Mouse.   PubMed:26471500 [IF=3.887] Yang LIU. et al. Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis. CHIN J NAT MEDICINES. 2023 Apr;21:263  IHC,IF ;  Mouse.   PubMed:37120245 [IF=3.69] Qingqing Chen. et al. Coptis chinensis Franch polysaccharides provide a dynamically regulation on intestinal microenvironment, based on the intestinal flora and mucosal immunity. J Ethnopharmacol. 2021 Mar;267:113542  IHC ;  Rat.   PubMed:33152428 [IF=3.642] Emin Kaymak. et al. Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin. 2021 Aug 15  IHC ;  Rat.   PubMed:34392583 [IF=3.457] Zheng X et al. Dendritic cells and Th17/Treg ratio play critical roles in pathogenic process of chronic obstructive pulmonary disease. (2018) Biomedicine & Pharmacotherapy.108,1141–1151.  IHC ;  Human.   PubMed:30372815 [IF=3.411] Zhou Yonglong. et al. Mechanism of Catechol-O-methyltransferase Regulating Orofacial Pain Induced by Tooth Movement. Biomed Res Int. 2021;2021:4229491  other ;  Rat.   PubMed:34725639 [IF=3.298] Qiu et al. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. (2018) J.Immunol.Res. 2018:2952471  IHC ;  Rat.   PubMed:29682587 [IF=2.61] Wang N et al. CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE. Immunol Res. 2019 Dec;67(6):486-496.  IHC-P ;  Mouse.   PubMed:31919790 [IF=2.55] Chen, Baiwen, et al. "Effects of 1, 25-dihydroxyvitamin D3 in an ovalbumin-induced allergic rhinitis model." International Immunopharmacology 47 (2017): 182-189.  IHC-F ;  Mouse.   PubMed:28412624 [IF=2.502] Pu J et al. FGF-7 facilitates the process of psoriasis by inducing TNF-α expression in HaCaT cells. Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(10):1056-1063.  WB ;  Mouse.   PubMed:31555794 [IF=1.922] Zhu C et al. Roseburia intestinalis inhibits interleukin‑17 excretion and promotes regulatory T cells differentiation in colitis.Mol Med Rep. 2018 Jun;17(6):7567-7574.  IHC-P ;  Mouse.   PubMed:29620246 [IF=1.834] Emin Kaymak. et al. Thymoquinone alleviates doxorubicin induced acute kidney injury by decreasing endoplasmic reticulum stress, inflammation and apoptosis. BIOTECH HISTOCHEM. 2022 Aug 22  IHC ;  Mouse.   PubMed:35989671 [IF=1.703] Zhao Jian. et al. The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats. NEUROREPORT. 2022 Aug;33(12):534-542  IHC, WB ;  Rat.   PubMed:35882013 [IF=1.69] Liao, Yanxi, et al. "Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway." Molecular Medicine Reports.  WB ;  Rat.   PubMed:29039526 [IF=1.55] Yang, Lijuan, et al. "Effect of IL-17 in the development of colon cancer in mice." Oncology Letters 12.6 (2016): 4929-4936.  WB ;  Mouse.   PubMed:28101230 [IF=1.396] Xiong Y et al. Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.(2018) Int J Clin Exp Pathol;11(10):4817-4826.  FC&IHC ;  Mouse.   PubMed:ISSN:1936-2625/IJCEP0080924
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	15kDa
Detection molecular weight	15-17 kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse IL-17: 85-150/150
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020] Function: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Subunit: Homodimer. Subcellular Location: Secreted. Tissue Specificity: Restricted to a subset of activated T-cells. Post-translational modifications: Found both in glycosylated and nonglycosylated forms. Similarity: Belongs to the IL-17 family. SWISS: Q62386 Gene ID: 16171 Database links: Entrez Gene: 3605 Human Entrez Gene: 16171 Mouse Entrez Gene: 301289 Rat Omim: 603149 Human SwissProt: Q16552 Human SwissProt: Q62386 Mouse SwissProt: Q61453 Rat Unigene: 41724 Human Unigene: 5419 Mouse Unigene: 218513 Rat 白细胞介素17（IL-17A）是一种来源于活化Tlymphocyte的cell factor,具有较广泛的生物学活性,它能够通过诱导基质细胞产生前炎性cell factor和造血cell factor参与机体免疫调节及部分炎症反应，因此白细胞介素IL-17A可能是某些疾病发生发展的重要因素之一。Interleukin-17 原称CTLA-8, 是T细胞表达的多肽，参与造血干系统的调节，已经显示IL-17促进纤维母细胞产生IL-6，IL-8和G-CSF。
Product Picture	Sample: Lane 1: Rat Lymph node tissue lysates Lane 2: Mouse Lymph node tissue lysates Lane 3: Rat Thymus tissue lysates Primary: Anti-IL17A (SL1183R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 15 kD Observed band size: 22 kD Tissue/cell: rat tongue tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(SL1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-17/IL-17A Polyclonal Antibody, Unconjugated(SL1183R) 1:600, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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