Product Name	CRMP3
Chinese Name	二氢嘧啶酶相关蛋白3抗体
Alias	Collapsin response mediator protein 3; CRMP 3; CRMP-3; CRMP3; Dihydropyrimidinase like 4; Dihydropyrimidinase related protein 4; Dihydropyrimidinase-related protein 4; DPYL4_HUMAN; DPYSL4; DRP 4; DRP-4; DRP4; ULIP 4; ULIP-4; ULIP4; UNC33 like phosphoprotein 4; UNC33-like phosphoprotein 4.
literatures	Specific References  (1)     |     SL11821R has been referenced in 1 publications. [IF=3.171] Zhi-Sheng Ji. et al. Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching. Neural Regen Res. 2021 Apr;16(12):2549  IP ;  Rat.   PubMed:33907047
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CRMP3: 6-100/572
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia. Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Subcellular Location: Cytoplasm. Tissue Specificity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. SWISS: O14531 Gene ID: 10570 Database links: Entrez Gene: 10570 Human Entrez Gene: 26757 Mouse Entrez Gene: 25417 Rat Omim: 608407 Human SwissProt: O14531 Human SwissProt: O35098 Mouse SwissProt: Q62951 Rat Unigene: 100058 Human Unigene: 250414 Mouse Unigene: 10503 Rat
Product Picture	Sample: Ovary(Mouse)Lysate at 40 ug Cerebrum (Mouse)Lysate at 40 ug Primary: Anti-CRMP3(SL11821R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 62kD Observed band size: 62kD Sample: DU145 (Human)Cell Lysate at 40 ug A549 (Human) Cell Lysate at 40 ug Primary: Anti-CRMP3(SL11821R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 62kD Observed band size: 62kD

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