TEL: +86 571 56623320 EMAIL: [email protected]
Product Name CHRDL1 Chinese Name 脊索生成素样蛋白1抗体 Alias CHL; chordin like 1; Chordin-like protein 1; CHRDL1; CRDL1_HUMAN; dA141H5.1; neuralin 1; Neuralin-1; Neurogenesin-1; NRLN1; Ventroptin; VOPT. literatures Specific References (1) | SL11819R has been referenced in 1 publications.[IF=0] Bhutani, Nidhi, et al. "USE OF CHORDIN-LIKE 1 OR COLLAGEN VI WITH MESENCHYMAL STEM CELLS." U.S. Patent No. 20,170,209,621. 27 Jul. 2017. Human.Research Area Cell biology Developmental biology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 49kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CHRDL1: 21-120/450 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The patterning of the central nervous system (CNS) relies on the interaction of multiple signaling molecules, including Shh (sonic hedgehog homolog), Wnt proteins and BMPs (bone morphogenetic proteins), with their antagonists, namely chordin and Noggin. Chordin is a key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like BMPs and sequestering them in latent complexes. CHRDL1 (Chordin-like protein 1), also known as CHL, VOPT (Ventroptin) or NRLN1 (Neuralin-1), is a 450 amino acid secreted protein that contains three VWFC domains. Functioning in a similar manner to chordin, CHRDL1 binds to BMP-4 and prevents the interaction of BMP-4 with its target receptors, thereby antagonizing BMP-4 activity. Additionally, CHRDL1 is thought to play a role in dorsoventral axis formation, embryonic bone formation and angiogenesis, as well as in the differentiation of neural stem cells.
Function:
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in the developing cornea and in the eye anterior segment in addition to the retina. Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in retinal pericytes.
Similarity:
Contains 3 VWFC domains.
SWISS:
Q9BU40
Gene ID:
91851
Database links:Entrez Gene: 91851 Human
Entrez Gene: 83453 Mouse
Omim: 300350 Human
SwissProt: Q9BU40 Human
SwissProt: Q920C1 Mouse
Unigene: 496587 Human
Scan Wechat Qrcode