Product Name	CELSR2
Chinese Name	表皮生长因子样蛋白2抗体
Alias	Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog; Cadherin EGF LAG seven-pass G-type receptor 2; Cadherin family member 10; CDHF10; CELR2_HUMAN; Celsr2; EGF like domain multiple 2; EGF-like protein 2; EGFL2; epidermal growth factor like 2; Epidermal growth factor-like protein 2; Flamingo homolog 3; Flamingo1; KIAA0279; MEGF3; Multiple EGF-like domains protein 3; Multiple epidermal growth factor-like domains protein 3.
Research Area	Neurobiology  Signal transduction  Channel protein  The cell membrane受体  G protein-coupled receptor  Cytoskeleton  Extracellular matrix  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	314kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CELSR2: 201-300/2923 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Drosophila Flamingo is a seven pass transmembrane cadherin that is necessary for dendritic patterning and axon guidance. Flamingo mammalian homo-logs play similar roles in neuronal development, during which they play an important role in cell-cell signaling. Cadherin EGF LAG seven pass G-type receptors (CELSRs) are multi-pass membrane proteins that belong to the G protein-coupled receptor family of proteins. Silencing CELSR2 gene ex-pression results in signficant simplification of dendritic arbors of cortical pyramidal neurons and Purkinje neurons, which may be due to branch retraction. In mouse, CELSR1, CELSR2 and CELSR3 are expressed in the nervous system at early developmental stages, and show expression patterns in the developing CNS. CELSR2 is distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells and olfactory neurons. Function: Receptor that may have an important role in cell/cell signaling during nervous system formation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highest expression in brain and testis. Post-translational modifications: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 9 cadherin domains. Contains 7 EGF-like domains. Contains 1 GPS domain. Contains 1 laminin EGF-like domain. Contains 2 laminin G-like domains. SWISS: Q9HCU4 Gene ID: 1952 Database links: Entrez Gene: 100061311 Horse Entrez Gene: 1952 Human Entrez Gene: 53883 Mouse Entrez Gene: 83465 Rat Omim: 604265 Human SwissProt: Q9HCU4 Human SwissProt: Q9R0M0 Mouse SwissProt: Q9QYP2 Rat Unigene: 57652 Human Unigene: 39728 Mouse Unigene: 222746 Rat

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