Product Name	Tmem18
Chinese Name	Transmembrane protein18抗体
Alias	DKFZp434C1714; TMEM18; TMM18_HUMAN; Transmembrane protein 18.
Research Area	Neurobiology  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Tmem18: 41-140/140
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TMEM18 is a 140 amino acid multi-pass membrane protein that localizes to the nuclear membrane and is expressed in the brain. TMEM18 functions as a cell migration modulator which enhances the glioma-specific migration ability of neural precursor and neural stem cells.Overexpression of TMEM18 increases migration of human and murine neural stem cells, whereas knockdown of TMEM18 mRNA reduces cellular migration. Two specific single nucleotide polymorphisms (SNPs) within the TMEM18 gene locus known as rs6548238 and rs756131 have been linked to obesity susceptibility. Function: Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). Subunit: Forms homooligomers, independently of the DNA-binding domain. Subcellular Location: Cytoplasm. Nucleus membrane; Multi-pass membrane protein. Similarity: Belongs to the TMEM18 family. SWISS: Q96B42 Gene ID: 129787 Database links: Entrez Gene: 129787 Human Entrez Gene: 211986 Mouse Entrez Gene: 362722 Rat Omim: 613220 Human SwissProt: Q96B42 Human SwissProt: Q3TUD9 Mouse SwissProt: Q6DGF8 Rat Unigene: 43899 Human Unigene: 34035 Mouse Unigene: 207403 Rat

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