Product Name	EBF2
Chinese Name	早期Blymphocyte因子2抗体
Alias	COE 2; COE2; Collier Olf and EBF 2; Early B cell factor 2; EBF 2; FLJ11500; Metencephalon mesencephalnon olfactory transcription factor 1; O/E 3; O/E3; OE 3; OE3; OLF 1/EBF like 3; Transcription factor COE2; COE2_HUMAN.
literatures	Specific References  (2)     |     SL11740R has been referenced in 2 publications. [IF=14.919] Chen, Yan-Ting. et al. Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance. Nat Commun. 2021 Nov;12(1):1-18  FC ;  Mouse.   PubMed:34824246 [IF=6.78] Andrea Estefanía Portales. et al. CDK4/6 are necessary for UCP1-mediated thermogenesis of white adipose tissue. LIFE SCI. 2023 Jun;322:121652  FC ;  Mouse.   PubMed:37011871
Research Area	Cell biology  Neurobiology  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	63kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human EBF2: 331-400/575
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Early B-cell factor 2 is a 575 amino acid protein belonging to the COE family of proteins, whose members are all helix-loop-helix transcription factors. EBF2 is a transcription factor which, in synergy with the Wnt-responsive LEF1/CTNNB1 pathway, activates the decoy receptor for RANKL, OPG, in osteoblasts. OPG, in turn, regulates osteoclast differentiation. Lack of EBF2 has been found to cause a small defect in the terminal differentiation of osteoblasts, along with reduced bone mass and an increase in osteoclasts. Localized to the nucleus, EBF2 forms a homodimer or a heterodimer with a related family member. Function: EBF2 (Early B-cell factor 2) belongs to the conserved Olf/EBF family of helix-loop-helix transcription factors. In osteoblasts it activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. EBF2 acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. It recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Subunit: Forms either a homodimer or a heterodimer with a relatedfamily member Subcellular Location: Nuclear Similarity: Belongs to the COE family. Contains 1 IPT/TIG domain. SWISS: Q9HAK2 Gene ID: 64641 Database links: Entrez Gene: 519342 Cow Entrez Gene: 64641 Human Entrez Gene: 13592 Mouse Entrez Gene: 373696 Xenopus laevis Entrez Gene: 394808 Xenopus tropicalis Omim: 609934 Human SwissProt: Q08DL5 Cow SwissProt: Q9HAK2 Human SwissProt: O08792 Mouse SwissProt: B7ZRI2 Xenopus laevis SwissProt: O73741 Xenopus laevis SwissProt: Q6P4K7 Xenopus tropicalis

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