Product Name	Calcyon
Chinese Name	多巴胺D1受体相互作用蛋白抗体
Alias	CALCYON; Drd1ip; Caly; CALY_HUMAN; D1 dopamine receptor interacting protein; Drd1ip; Neuron specific vesicular protein calcyon; Neuron-specific vesicular protein calcyon; NSG3; RP11-122K13.5.
Research Area	Neurobiology  The cell membrane受体  Transmembrane protein  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Calcyon: 3-65/217 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Calcyon is a single transmembrane protein that interacts with D1 dopamine receptors. Dopamine is a neurotransmitter that regulates synaptic transmission involved in learning and memory. D1 receptors, the most abundant dopamine receptor in the central nervous system, appear to modulate the activity of D2 dopamine receptors, mediate various behavioural responses, and regulate neuron growth and differentiation. Calcyon is present in neuronal cell bodies and processes of the cortex and hippocampus, and it is especially abundant in pyramidal neurons. Interaction of Calcyon with D1 receptors results in a release of intracellular calcium. Function: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. Subunit: nteracts with CLTA. Subcellular Location: Cytoplasmic vesicle membrane. Cell membrane. Tissue Specificity: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non-schizophrenics. Post-translational modifications: Glycosylated. Similarity: Belongs to the NSG family. SWISS: Q9NYX4 Gene ID: 50632 Database links: Entrez Gene: 50632 Human Entrez Gene: 68566 Mouse Entrez Gene: 192349 Rat Omim: 604647 Human SwissProt: Q9NYX4 Human SwissProt: Q9DCA7 Mouse SwissProt: P58821 Rat Unigene: 148680 Human Unigene: 44241 Mouse Unigene: 27756 Rat

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