Product Name	CCR-1/CD191
Chinese Name	细胞表面Chemokine受体1抗体
Alias	CC chemokine receptor 1; A630091E18Rik; CC-CKR-11; CCBP2; CCR10; CCR11; CCRL1; CCX-CKR; CCX-CKR1; CKR-11; Cmkbrl1; LOC684092; LOC685243; PPR1; VSHK1; C C chemokine receptor type 1; C C CKR 1; CC CKR 1; CCR 1; CD 191; CD191; CD191; Chemokine (C-C motif) receptor 1; Chemokine C C motif receptor 1; CKR 1; CKR1; CMKBR 1; CMKBR1; CMKR 1; CMKR1; HM145; LD78 receptor; Macrophage inflammatory protein 1 alpha /Rantes receptor; Macrophage inflammatory protein 1 alpha receptor; MIP 1alpha R; Mip-1a-R; MIP1aR; RANTES R; RANTES receptor; SCYAR1; CCR1_HUMAN; C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; Short=CCR-1; CCR1; LD78 receptor; MIP-1alpha-R; RANTES-R; CD191.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CCR-1: 301-355/355
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] Function: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Subunit: Interacts with CREB3. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in different hematopoietic cells. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P32246 Gene ID: 1230 Database links: Entrez Gene: 1230 Human Entrez Gene: 12768 Mouse Omim: 601159 Human SwissProt: P32246 Human SwissProt: P51675 Mouse Unigene: 301921 Human Unigene: 274927 Mouse Chemokine是当今cell factorResearch Area的热点之一,它参与多种免疫及炎症反应,在感染、Tumour的生长与转移、组织修复及创伤愈合等病理生理过程中发挥重要作用. C-C型Chemokine受体1(CCR1)主要在嗜酸粒细胞，Th2lymphocyte，肥大细胞，支气管epithelial cells上表达.CCR1在Tumour的生长与转移方面起到一定的作用.
Product Picture	Sample: lymph (Mouse) Lysate at 40 ug Primary: Anti-CCR-1 (SL1169R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 40 kD Observed band size: 46 kD Sample: Bones (Mouse) Lysate at 40 ug Primary: Anti- CCR-1 (SL1169R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/10000 dilution Predicted band size: 40 kD Observed band size: 45 kD Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CCR1 Polyclonal Antibody, Unconjugated(SL1169R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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