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Product Name PCYT2 Chinese Name 磷酸乙醇胺转移酶2抗体 Alias CTP; phosphoethanolamine cytidylyltransferase; ET; Ethanolamine-phosphate cytidylyltransferase; Ethanolaminephosphate Cytidyltransferase; PCY2; PCY2_HUMAN; Pcyt2; Phosphate cytidylyltransferase 2 ethanolamine; Phosphorylethanolamine transferase. Research Area Cardiovascular Cell biology Neurobiology Signal transduction Alzheimer's Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 44kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PCYT2: 315-389/389 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Phosphatidylethanolamine (PtdEtn) is a major membrane phospholipid which serves to play a primary role in cell membrane structure and is also involved in cell division, cell signaling, activation, phagocytosis and autophagy. PCYT2 (Phosphorylethanolamine transferase), also known as Ethanolamine-phosphate cytidylyltransferase, is a 389 amino acid protein that catalyzes the formation of CDP-ethanolamine from ethanolamine. This product combined with diacylglycerol form phosphatidylethanolamine via the de novo Kennedy pathway. PCYT2 is expressed at highest levels in heart, liver and skeletal muscle. Elevated levels of MyoD, reduced content of Sp1 and a changed ratio of Sp1 to Sp3 all together stimulate upregulation of PCTY2 transcription during C2C12 muscle cell differentiation. Disruption of the PCYT2 gene in mice leads to death after embryo implantation, establishing the necessity of PCYT2 for murine development.
Function:
Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.
Tissue Specificity:
Strongest expression in liver, heart, and skeletal muscle.
Similarity:
Belongs to the cytidylyltransferase family.
SWISS:
Q99447
Gene ID:
5833
Database links:Entrez Gene: 5833 Human
Entrez Gene: 68671 Mouse
SwissProt: Q99447 Human
SwissProt: Q922E4 Mouse
Unigene: 569843 Human
Unigene: 21439 Mouse
Unigene: 7291 Rat
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