Product Name	ARPC5
Chinese Name	肌动蛋白相关蛋白2/3复合体亚基5抗体
Alias	ARPC5_HUMAN; Actin-related protein 2/3 complex subunit 5; ARC16; p16 ARC; p16-Arc; Arp2/3 complex 16 kDa subunit (p16-ARC); dJ127C7.3;
literatures	Specific References  (1)     |     SL11652R has been referenced in 1 publications. [IF=2.751] Peibei Zhang. et al. PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model. EXP THER MED. 2023 May;25(5):1-10  IF ;  Mouse.   PubMed:10.3892/etm.2023.11922
Research Area	Cell biology  Signal transduction  Cytoskeleton  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human p16 ARC: 51-151/151
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] Function: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Subunit: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Subcellular Location: Cytoplasm, cytoskeleton. Cell projection. Similarity: Belongs to the ARPC5 family. SWISS: O15511 Gene ID: 10092 Database links: Entrez Gene: 10092 Human Entrez Gene: 67771 Mouse Entrez Gene: 360854 Rat Omim: 604227 Human SwissProt: O15511 Human SwissProt: Q9CPW4 Mouse SwissProt: Q4KLF8 Rat Unigene: 518609 Human Unigene: 288974 Mouse Unigene: 1639 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (p16 ARC) Polyclonal Antibody, Unconjugated (SL11652R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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