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Product Name TMEM59L Chinese Name Transmembrane protein59样蛋白抗体 Alias BSMAP; Brain-specific membrane-anchored protein; C19orf4; TM59L_HUMAN; Tmem59l; Transmembrane protein 59-like. Research Area Neurobiology Signal transduction Alzheimer's Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 35kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TMEM59L: 251-342/342 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail BSMAP is a 342 amino acid type-I membrane glycoprotein that localizes to organelle membranes and belongs to the TMEM59 family. Expressed at high levels in brain tissue, BSMAP is thought to play a role in brain function and central nervous system activity. The gene encoding BSMAP maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).
Function:
Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Expressed preferentially at high level in the brain.
Post-translational modifications:
Belongs to the TMEM59 family.
Similarity:
Belongs to the TMEM59 family.
SWISS:
Q9UK28
Gene ID:
25789
Database links:Entrez Gene: 25789 Human
Entrez Gene: 67937 Mouse
SwissProt: Q9UK28 Human
SwissProt: Q7TNI2 Mouse
Unigene: 329850 Human
Unigene: 23002 Mouse
Unigene: 203070 Rat
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