Product Name	HCN2 + HCN4
Chinese Name	环化核苷酸调控阳离子Channel protein亚型2/4抗体
Alias	HCN2+HCN4; HCN2 / HCN4; HCN2+4; HCN2/4; BCNG 2; Brain cyclic nucleotide gated channel 2; HAC 1; HCN 4; HCN 2; Hyperpolarization activated cyclic nucleotide gated potassium channel 4;HCN2_HUMAN; HCN4_HUMAN.
literatures	Specific References  (1)     |     SL11630R has been referenced in 1 publications. [IF=1.468] Fei-Fei Wang. et al. Aging-induced atrial fibrosis in If current change and its effect on atrial fibrillation in dogs. ANN NONINVAS ELECTRO. 2022 Apr 11  WB ;  Mouse.   PubMed:35403309
Research Area	Cardiovascular  Cell biology  Neurobiology  Signal transduction  Channel protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Chicken, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	97+129kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HCN2 + HCN4: 151-250/889
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Hyperpolarization activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. HCN4 is another member of the family of hyperpolarization activated and cyclic nucleotide gated channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node. Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2 Subcellular Location: Membrane; Multi pass membrane protein. Tissue Specificity: Highly expressed throughout the brain. Detected at low levels in heart. Similarity: Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. SWISS: Q9UL51 Gene ID: 610 Database links: Entrez Gene: 10021 Human Entrez Gene: 610 Human Entrez Gene: 15166 Mouse Entrez Gene: 330953 Mouse Entrez Gene: 114244 Rat Entrez Gene: 59266 Rat Omim: 602781 Human Omim: 605206 Human SwissProt: Q9UL51 Human SwissProt: Q9Y3Q4 Human SwissProt: O70507 Mouse SwissProt: O88703 Mouse SwissProt: Q9JKA7 Rat SwissProt: Q9JKA9 Rat
Product Picture	Sample: Cerebrum (Mouse) Lysate at 40 ug Cerebrum (Rat) Lysate at 40 ug Cerebral cortex (Mouse) Lysate at 40 ug Primary: Anti- HCN2 + HCN4 (SL11630R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 97/129 kD Observed band size: 97 kD

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