Product Name	SOX6
Chinese Name	核转录因子SOX6抗体
Alias	HSSOX 6; HSSOX6; SOX-6 SOX 6; SOX6_HUMAN.
Research Area	Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	92kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SOX6: 1-100/828
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Function: Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation. Subunit: Interacts with DAZAP2 Subcellular Location: Nucleus. Tissue Specificity: Expressed in a wide variety of tissues, most abundantly in skeletal muscle. Post-translational modifications: Sumoylation inhibits the transcriptional activity. Similarity: Contains 1 HMG box DNA-binding domain. SWISS: P35712 Gene ID: 55553 Database links: Entrez Gene: 55553 Human Entrez Gene: 20679 Mouse Entrez Gene: 293165 Rat Omim: 607257 Human SwissProt: P35712 Human SwissProt: P40645 Mouse SwissProt: Q8BSS6 Mouse SwissProt: Q4V8G3 Rat Unigene: 368226 Human Unigene: 323365 Mouse

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