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Product Name DISP2 Chinese Name TransporterDISP2抗体 Alias DISP 2; Dispatched B; Dispatched homolog 2 (Drosophila); Dispatched homolog 2; DISPB; DKFZp547N223; HsT16908; KIAA1742; Protein dispatched homolog 2; DISP2_HUMAN. Research Area Tumour Cell biology Signal transduction transcriptional regulatory factor Cell Surface Molecule Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 152kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human DISP2: 1101-1200/1401 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the dispatched family.
Contains 1 SSD (sterol-sensing) domain.
SWISS:
A7MBM2
Gene ID:
85455
Database links:Entrez Gene: 85455 Human
Entrez Gene: 214240 Mouse
Omim: 607503 Human
SwissProt: A7MBM2 Human
SwissProt: Q8CIP5 Mouse
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