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Product Name SOX14 Chinese Name 核转录因子SOX14抗体 Alias HMG box transcription factor SOX 14; SOX 14; SOX 28; Sox box protein 14; SOX28; SRY (sex determining region Y) box 14; SRY box 14; Transcription factor SOX 14; SOX14_HUMAN. Research Area Cell biology Neurobiology Signal transduction transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 26kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SOX14: 51-150/240 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Function:
The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate (specifically neuronal). SOX14 is most closely related to SOX factors 1,2 and 3 and likely mirrors expression of these genes in the developing brain and spinal cord.
Subcellular Location:
Nuclear
Similarity:
Contains 1 HMG box DNA-binding domain.
SWISS:
O95416
Gene ID:
8403
Database links:Entrez Gene: 395526 Chicken
Entrez Gene: 8403 Human
Entrez Gene: 20669 Mouse
Omim: 604747 Human
SwissProt: Q9W7R6 Chicken
SwissProt: O95416 Human
SwissProt: Q04892 Mouse
Unigene: 248184 Human
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