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Product Name PTPRN Chinese Name 蛋白酪氨酸磷酸酶样N前体蛋白抗体 Alias PTPIA2; RPTPN; TPIA2; CA 512; IA 2; IA 2/PTP; IA2; IA2/PTP; ICA 3; ICA 512; ICA3; ICA512; Islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; Protein tyrosine phosphatase like N; Protein tyrosine phosphatase like N precursor; Protein tyrosine phosphatase receptor type N; PTP IA 2; PTP IA-2; PTP IA2; PTPIA 2; PTPN; Ptprn; PTPRN protein; PTPRN_HUMAN; R PTP N; R-PTP-N; Receptor type tyrosine protein phosphatase like N; Receptor-type tyrosine-protein phosphatase-like N. Research Area Tumour Neurobiology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Pig, Cow, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3μg/Test ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 102kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TPIA2: 501-600/979 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Function:
Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2.
Subunit:
Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage.
Subcellular Location:
Membrane. Neuroendocrine secretory granules.
Tissue Specificity:
Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary.
Post-translational modifications:
Appears to undergo multiple proteolytic cleavage at consecutive basic residues.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
Contains 1 tyrosine-protein phosphatase domain.
SWISS:
Q16849
Gene ID:
5798
Database links:Entrez Gene: 5798 Human
Entrez Gene: 19275 Mouse
Omim: 601773 Human
SwissProt: Q16849 Human
SwissProt: Q60673 Mouse
Unigene: 89655 Human
Unigene: 2902 Mouse
Unigene: 11097 Rat
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