Product Name	Ghrelin Receptor
Chinese Name	脑肠肽受体抗体
Alias	GH releasing peptide receptor; GH-releasing peptide receptor; Ghrelin receptor; GHRP; GHRPR; GHS-R; GHS-R1; GHSR; GHSR_HUMAN; Growth hormone secretagogue receptor 1; Growth hormone secretagogue receptor type 1; growth hormone secretatgogue receptor.
literatures	Specific References  (7)     |     SL11529R has been referenced in 7 publications. [IF=5.81] Shengyan Xi. et al. The Ciji-Hua’ai-Baosheng II Formula Attenuates Chemotherapy-Induced Anorexia in Mice With H22 Hepatocellular Carcinoma. Front Pharmacol. 2021; 12: 715824  IHC ;  Mouse.   PubMed:34489705 [IF=4.994] He Zhang. et al. Effect of feeding regimen on circadian activity rhythms of food anticipatory by ghrelin hormone in a pig model. 2022 Mar 05  WB ;  Pig.   PubMed:35249475 [IF=4.546] Quancheng Liu. et al. FumDSB Can Reduce the Toxic Effects of Fumonisin B1 by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs. Toxins. 2021 Dec;13(12):874  WB,IHC ;  Pig.   PubMed:34941712 [IF=2.784] Liu et al. Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B. (2018) Int.J.Mol.Med. 42:3037-3046  WB&IHC ;  Rat.   PubMed:30272367 [IF=2.407] Su MQ et al. Ghrelin fiber projections from the hypothalamic arcuate nucleus into the dorsal vagal complex and the regulation of glycolipid metabolism. Neuropeptides,2019,September 15, 101972.  IHF ;  Rat.   PubMed:31610887 [IF=2.146] Liu X et al. The role of acylated ghrelin and unacylated ghrelin in the blood and hypothalamus and their interaction with nonalcoholic fatty liver disease. Iran J Basic Med Sci . 2020 Sep;23(9):1191-1196.  WB ;  Rat.   PubMed:32963741 [IF=2.092] Brito Rosiane F. et al. Performance and serum parameters of calves (Bos taurus) subject to milk restriction associated with supplementation with 2-hydroxy-4-methylthiobutanoic acid. J Anim Sci. 2021 Apr;:  WB,IHC ;  Bovine.   PubMed:33914885
Research Area	Tumour  Neurobiology  Signal transduction  Growth factors and hormones  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Ghrelin Receptor: 75-135/366 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the G-protein coupledreceptor family. The encoded protein may play a role in energyhomeostasis and regulation of body weight. Two identifiedtranscript variants are expressed in several tissues and areevolutionary conserved in fish and swine. One transcript, 1a,excises an intron and encodes the functional protein; this proteinis the receptor for the Ghrelin ligand and defines a neuroendocrinepathway for growth hormone release. The second transcript (1b)retains the intron and does not function as a receptor for Ghrelin;however, it may function to attenuate activity of isoform 1a.Mutations in this gene are associated with autosomal idiopathicshort stature.[provided by RefSeq, Apr 2010]. Function: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). Subcellular Location: Cell membrane. Tissue Specificity: Pituitary and hypothalamus. DISEASE: Defects in GHSR may be a cause of idiopathic short stature autosomal (ISSA) [MIM:604271]. Short stature is defined by a subnormal rate of growth. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q6ISR8 Gene ID: 2693 Database links: Entrez Gene: 2693 Human Entrez Gene: 208188 Mouse Entrez Gene: 397372 Pig Entrez Gene: 84022 Rat Omim: 601898 Human SwissProt: Q6ISR8 Human SwissProt: Q92847 Human SwissProt: Q99P50 Mouse SwissProt: Q95254 Pig SwissProt: O08725 Rat Unigene: 130212 Human Unigene: 194721 Mouse Unigene: 16107 Pig Unigene: 74241 Rat

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