Product Name	NPY5R
Chinese Name	神经肽Y受体5抗体
Alias	Neuropeptide Y receptor type 5; Neuropeptide Y receptor Y5; NPY 5R; NPY R5; NPY Y5; NPY Y5 receptor; NPY-Y5 receptor; NPY5 R; NPY5-R; NPY5R; NPY5R_HUMAN; NPYR 5; NPYR5; NPYY 5; NPYY5; NPYY5-R; Y5 receptor.
Research Area	Cell biology  Neurobiology  Signal transduction  Channel protein  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	51kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NPY5R: 1-100/445 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY) are related 36-amino acid hormones. A number of structurally related receptors for these peptides have been isolated, NPY1-R, NPY2-R, NPY3-R, NPY4-R, NPY5-R, and NPY6-R. NPY4-R is expressed in several human tissues, including brain, coronary artery, and ileum. NPY4-R maps to human chromosome 10q11.2. NPY-5R, isolated from rat hypothalamus, encodes a 456-amino acid protein with less than 35% overall identity to known Y-type receptors. The human NPY5-R sequence is nearly identical to, but in the opposite orientation from, that of the human NPY1-R sequence. NPY5-R localizes to the paraventricular hypothalamic nucleus, the lateral hypothalamus, and other locations consistent with a role in the control of feeding behavior. The gene which encodes NPY5-R maps to human chromosome 4q32.2. NPY6-R is abundantly expressed in human heart and skeletal muscle and the gene which encodes NPY6-R maps to human chromosome 5q31. Function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Brain; hypothalamus. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q15761 Gene ID: 4889 Database links: Entrez Gene: 4889 Human Entrez Gene: 18168 Mouse Entrez Gene: 25340 Rat Omim: 602001 Human SwissProt: Q15761 Human SwissProt: O70342 Mouse SwissProt: Q63634 Rat Unigene: 519058 Human Unigene: 598503 Human Unigene: 10685 Mouse Unigene: 10532 Rat
Product Picture	Sample: Cerebellum (Mouse) Lysate at 40 ug Primary: Anti- NPY5R (SL11521R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kD Observed band size: 53 kD Sample: U87MG(Human) Cell Lysate at 30 ug Primary: Anti- NPY5R (SL11521R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kD Observed band size: 53 kD

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