Product Name	Torsin B
Chinese Name	扭转蛋白B抗体
Alias	DQ1; Tor1b; Torsin 1B; TOR1B; FKSG18; Torsin family 1 member B; TOR1B_HUMAN.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Torsin B: 281-336/336
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TorsinB is a 336 amino acid protein that localizes to the lumen of endoplasmic reticulum and belongs to the Torsin family. Expressed in a variety of tissues with particularly high levels in adult brain, TorsinB is thought to function as a molecular chaperone that assists in the conformational folding of membrane and secreted proteins. Via its ability to regulate protein folding, TorsinB plays a key role in postnatal developmental events and is essential for proper neurological development. TorsinB contains two PKC (protein kinase C) phosphorylations sites, one ATP binding domain and several conserved cysteines and shares 69% amino acid identity with TorsinA, a related family member. Defects in the gene encoding TorsinB are associated with torsion dystonia, an autosomal dominant neurological disorder that is characterized by debilitating muscle contractions throughout the body. Function: Torsins are members of the AAA(+) superfamily of ATPases and are present in all multicellular organisms. Torsin B is an ER protein involved implicated in neurogenesis, neuronal migration, axon/dendrite development and synaptogenesis. Subcellular Location: Endoplasmic reticulum and nuclear envelope Tissue Specificity: Widely expressed with low levels in brain. Not detected in fetal brain. Similarity: Belongs to the clpA/clpB family. Torsin subfamily. SWISS: O14657 Gene ID: 27348 Database links: Entrez Gene: 27348 Human Entrez Gene: 30934 Mouse Omim: 608050 Human SwissProt: O14657 Human SwissProt: Q9ER41 Mouse Unigene: 252682 Human Unigene: 249164 Mouse
Product Picture	Sample: Placenta (Mouse) Lysate at 40 ug Uterus (Mouse) Lysate at 40 ug Primary: Anti-Torsin B (SL11491R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kD Observed band size: 40 kD

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