Product Name	Slit1
Chinese Name	多重表皮生长因子样蛋白4抗体
Alias	MEGF 4; MEGF4; Multiple EGF like domains protein 4; Multiple epidermal growth factor like domains 4; Multiple epidermal growth factor like domains protein 4; SLIL 1; SLIL1; Slit 1; SLIT 3; Slit homolog 1; Slit homolog 1 protein; Slit-1; Slit1; SLIT3; KIAA0813; SLIT1_HUMAN.
Research Area	Cell biology  Developmental biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	164kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Slit1/MEGF4: 455-500/1534
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Secreted leucine-rich repeat-containing proteins 1-3 (Slit1-3) are secreted glycoproteins that influence axonal guidance and mediate normal neural development by acting as high-affinity signaling ligands for the repulsive guidance receptor, Roundabout (Robo) (1, 2). Within the developing central nervous system (CNS) of different vertebrate systems, Slit proteins are expressed in equivalent regions, suggesting a conserved function among vertebrate homologs (3,4). Slit is expressed in the midline of the central nervous system in both vertebrates and invertebrates, where it functions as a regulatory factor of mesodermal cell movement during gastrulation (5). Slit2 is a short range inhibitory guidance cue for retinal ganglion cell (RGC) axons that may mediate spatial progression of RGCs (6,7). Function: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Subunit: Interacts with ROBO1 and GREM1 Subcellular Location: Secreted. Tissue Specificity: Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 9 EGF-like domains. Contains 1 laminin G-like domain. Contains 20 LRR (leucine-rich) repeats. Contains 4 LRRCT domains. Contains 4 LRRNT domains. SWISS: O75093 Gene ID: 6585 Database links: Entrez Gene: 395293 Chicken Entrez Gene: 6585 Human Entrez Gene: 20562 Mouse Entrez Gene: 65047 Rat Entrez Gene: 380270 Xenopus laevis Omim: 603742 Human SwissProt: O75093 Human SwissProt: Q80TR4 Mouse SwissProt: O88279 Rat Unigene: 632082 Human Unigene: 40322 Mouse Unigene: 30002 Rat

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