Product Name	Semaphorin 3E
Chinese Name	轴突导向因子SEMA3E抗体
Alias	Coll 5; Coll5; KIAA0331; M sema H; M SEMAH; M SemaK; Msema H; MSEMAH; MSemaK; SEM3E_HUMAN; Sema domain immunoglobulin domain (Ig); Sema domain immunoglobulin domain (Ig) short basic domain secreted 3E; Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; SEMA3E; SEMAH; Semaphorin 3E; Semaphorin-3E; Semaphorin3E; Short basic domain secreted (semaphorin) 3E; SEM3E_HUMAN.
Research Area	Cell biology  Neurobiology  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	86kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SEMA3E/Semaphorin 3E: 401-450/775
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] Function: Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation Subunit: Interacts with PLXND1 Subcellular Location: Secreted. Similarity: Belongs to the semaphorin family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Sema domain. SWISS: O15041 Gene ID: 9723 Database links: Entrez Gene: 9723 Human Entrez Gene: 20349 Mouse Entrez Gene: 100524100 Pig Entrez Gene: 296789 Rat Entrez Gene: 535644 Cow Entrez Gene: 483387 Dog Omim: 608166 Human SwissProt: O15041 Human SwissProt: P70275 Mouse SwissProt: Q9QX23 Mouse Unigene: 528721 Human Unigene: 134093 Mouse Unigene: 214084 Rat
Product Picture	Sample: DU145(Human) Cell Lysate at 30 ug Primary: Anti- Semaphorin 3E (SL11480R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 86 kD Observed band size: 111 kD Sample: Lymph node (Mouse) Lysate at 40 ug Primary: Anti- Semaphorin 3E (SL11480R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 86 kD Observed band size: 111 kD

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