Product Name	ABLIM1
Chinese Name	肌动蛋白Binding protein1抗体
Alias	ABLIM 1; ABLIM; abLIM-1; ABLIM-L; ABLIM-M; ABLIM-S; ABLIM1; ABLM1_HUMAN; Actin binding double zinc finger protein; Actin binding LIM protein 1; Actin binding LIM protein family member 1; Actin-binding double zinc finger protein; Actin-binding double zinc finger protein; Actin-binding LIM protein 1; Actin-binding LIM protein family member 1; DKFZp781D0148; FLJ14564; KIAA0059; LIM actin binding protein 1; LIMAB 1; LIMAB1; Limatin; RGD1565768; RP11-317F20.1.
Research Area	Cell biology  Neurobiology  Signal transduction  Cytoskeleton  Extracellular matrix
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	88kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ABLIM1: 681-778/778
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The C. elegans protein Unc-115 mediates axon guidance by modulating the growth cone Actin cytoskeleton in response to signals received by growth cone receptors. The mammalian homolog of Unc-115 is the Actin-binding LIM protein family member 1 (ABLIM1, also designated Limatin). The ABLIM1 protein has an N-terminal domain that contains four double zinc finger motifs, which conform to the LIM motif consensus sequence. ABLIM1 binds to F-Actin through a dematin-like domain and is expressed in retina, brain and muscle tissue. There are four known isoforms of ABLIM1. The gene encoding ABLIM1 maps to a region of chromosome 10 associated with frequent loss of heterozygosity in human tumors, thus identifying ABLIM1 as a candidate tumor suppressor gene. ABLIM2 and ABLIM3 show highest expression in muscle and neuronal tissues, bind to F-Actin, and are localized on stress fibers. They also have been shown to enhance STARS (striated muscle activator of Rho signaling) dependent activation of serum-response factor (SRF), thereby modulating transcription. Function: May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance. Subunit: Binds F-actin. Interacts with ABRA. Subcellular Location: Cytoplasm. Cytoplasm > cytoskeleton. Associated with the cytoskeleton. Tissue Specificity: Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers. Similarity: Contains 1 HP (headpiece) domain. Contains 4 LIM zinc-binding domains. SWISS: O14639 Gene ID: 3983 Database links: Entrez Gene: 3983 Human Entrez Gene: 226251 Mouse Entrez Gene: 307989 Rat Omim: 602330 Human SwissProt: O14639 Human SwissProt: Q8K4G5 Mouse Unigene: 438236 Human Unigene: 538331 Human Unigene: 593868 Human Unigene: 217161 Mouse Unigene: 446592 Mouse Unigene: 40404 Rat

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