Product Name	DUOX2
Chinese Name	双氧化酶2/甲状腺氧化酶2抗体
Alias	Dual oxidase 2; Dual oxidase2; DUOX2; DUOX2_HUMAN; Large NOX 2; LNOX2; Long NOX 2; NADH/NADPH thyroid oxidase p138 tox; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; NOXEF2; p138 thyroid oxidase; P138 TOX; THOX2; Thyroid oxidase 2.
literatures	Specific References  (5)     |     SL11432R has been referenced in 5 publications. [IF=4.603] Zhang Xue. et al. DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3. Carcinogenesis. 2021 Feb;42(1):105-117  IHC ;  Human.   PubMed:32531052 [IF=4.603] Zhang X et al. DUOX2 promotes the progression of colorectal cancer cells by regulating the AKT pathway and interacting with RPL3. Carcinogenesis . 2020 Jun 12;bgaa056.  IHC ;  Human.   PubMed:32531052 [IF=2.819] Li et al. The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori. (2016) Dig.Dis.Sc. 61:2328-37  IHC ;  Human.   PubMed:27048452 [IF=1.859] Qi et al. DUOX2 Expression Is Increased in Barrett Esophagus and Cancerous Tissues of Stomach and Colon. (2016) Gastroenterol.Res.Prac. 2016:1835684  IHC ;  Human.   PubMed:26839536 [IF=1.817] Wei Xiuqin. et al. Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation. MEDICINE. 2022 Aug;101(32):e30028  IHC ;  Human.   PubMed:35960091
Research Area	Cell biology  Neurobiology  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	173kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DUOX2: 501-600/1548
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Dual oxidase 2 (DUOX2), also designated NADPH thyroid oxidase 2, p138 thyroid oxidase or large NOX2, localizes to the apical membrane of epithelial cells. DUOX1, also designated NADPH thyroid oxidase or large NOX1, and DUOX2 are multi-pass membrane proteins predominantly expressed in thyrocytes, tracheal surface epithelial cells as well as thyroid, colon, duodenum, trachea and bronchium. DUOX1 and DUOX2 generate hydrogen peroxide, which is crucial for thyroid peroxidase and lactoperoxidase. In mucosa, DUOX proteins are involved in thyroid hormone biosynthesis and lactoperoxidase-mediated antimicrobial defense. Defects in the gene encoding for DUOX2 cause congenital hypothyroidism (CH), a disorder characterized by a defect in hydrogen peroxide production in the thyroid gland. Function: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. Subunit: Interacts with TXNDC11, TPO and CYBA. Subcellular Location: Apical cell membrane. Localizes to the apical membrane of epithelial cells. Tissue Specificity: Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis. Post-translational modifications: N-glycosylated. DISEASE: Defects in DUOX2 are a cause of thyroid dyshormonogenesis 6 (TDH6) [MIM:607200]. A disorder due to a defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. Similarity: In the N-terminal section; belongs to the peroxidase family. Contains 3 EF-hand domains. Contains 1 FAD-binding FR-type domain. Contains 1 ferric oxidoreductase domain. SWISS: Q9NRD8 Gene ID: 50506 Database links: Entrez Gene: 50506 Human Entrez Gene: 79107 Rat Omim: 606759 Human SwissProt: Q9NRD8 Human SwissProt: Q9ES45 Rat Unigene: 71377 Human Unigene: 55542 Rat

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