Product Name	Synaptogyrin 1
Chinese Name	神经细胞囊泡循环蛋白1抗体
Alias	SNG1_HUMAN;Synaptogyrin-1;Syngr1.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	26kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Synaptogyrin 1: 51-150/580
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal isoforms (Synaptogyrin-1 and -3) and one ubiquitous isoform (Synaptogyrin-2). Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as cellugyrin, has a tyrosine phosphorylated C-terminal cytoplasmic tail and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. Synaptogyrin-4 is a 234 amino acid protein encoded by the SYNGR4 gene. Function: Involved in the regulation of short-term and long-term synaptic plasticity. Subcellular Location: Membrane; Multi-pass membrane protein. Melanosome. Cell junction, synapse. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Similarity: Belongs to the synaptogyrin family. Contains 1 MARVEL domain. SWISS: O43759 Gene ID: 9145 Database links: Entrez Gene: 610027 Dog Entrez Gene: 9145 Human Entrez Gene: 20972 Mouse Entrez Gene: 100626046 Pig Entrez Gene: 100427479 Rhesus monkey Omim: 603925 Human SwissProt: O43759 Human SwissProt: O55100 Mouse SwissProt: Q5R703 Orangutan 囊泡循环蛋白,Synaptogyrin又称p29，是均一分布于神经系统的突触囊泡蛋白，在神经元及神经内分泌细胞高度表达，它是酪氨酸激酶的一个重要的囊泡相关底物。synaptogyrin为多基因家族编码，异构体的cDNA序列同源性为32%～46％。人的囊泡循环蛋白 cDNA有一阅读框架，编码234个氨基酸，分子量约25,683Da，有四个跨膜域，N端与C端朝向囊泡的胞质面，无糖基化位点，蛋白分子胞浆尾的氨基酸序列与Syp有74％的同源性。

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