Product Name	Synaptogyrin 3
Chinese Name	神经细胞囊泡循环蛋白3抗体
Alias	SNG3_HUMAN; Synaptogyrin 3; Synaptogyrin-3; Synaptogyrin3; SYNGR 3; SYNGR3; SYNGR-3; MGC:20003; MGC20003; OTTHUMP00000158899.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Synaptogyrin 3: 101-200/229
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal (Synaptogyrins 1 and 3) and one ubiquitous (Synaptogyrin-2) isoform. Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as Cellugyrin has a tyrosine phosphorylated C-terminal cytoplasmic tail, and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. The SYNGR4 gene encodes for the 234 amino acid protein Synaptogyrin-4. Function: Involved in the positive regulation of dopamine transporter activity. Probably facilitates the physical and functional interactions of the transporter with the dopamine vesicular storage system, allowing a more efficient loading of the vesicles with extracellular dopamine after release. Subunit: Interacts (via N-terminus) with SLC6A3 (via N-terminus) (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Cell junction, synapse. Note=Found at the neuromuscular synapses (By similarity). Tissue Specificity: Expressed in brain and placenta. Similarity: Belongs to the synaptogyrin family. Contains 1 MARVEL domain. SWISS: O43761 Gene ID: 9143 Database links: Entrez Gene: 9143 Human Entrez Gene: 20974 Mouse Entrez Gene: 302975 Rat Omim: 603927 Human SwissProt: O43761 Human SwissProt: Q8R191 Mouse Unigene: 435277 Human Unigene: 26032 Mouse

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