TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Nova2 Chinese Name 神经TumourNova2抗原抗体 Alias ANOVA; Astrocytic NOVA1 like RNA binding protein; Gm1424; NOVA2_HUMAN. Research Area Cell biology Neurobiology Cell type markers Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Chicken, Dog, Rabbit, ) Applications ELISA=1:5000-10000 Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 49kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Nova2: 401-492/492 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).
Function:
NOVA2 may regulate RNA splicing or metabolism in a specific subset of developing neurons. It binds single strand RNA.
Subunit:
Interacts with PTBP2; the interaction is direct (By similarity).
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain. Expression restricted to astrocytes.
Similarity:
Contains 3 KH domains.
SWISS:
Q9UNW9
Gene ID:
4858
Database links:Entrez Gene: 4858 Human
Entrez Gene: 384569 Mouse
Omim: 601991 Human
SwissProt: Q9UNW9 Human
Unigene: 375439 Human
Unigene: 262724 Mouse
Product Picture Blank control(blue): RSC96(fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice).
Primary Antibody:Rabbit Anti- Nova2 antibody(SL11325R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
Scan Wechat Qrcode