Product Name	PHC2
Chinese Name	早期发育调控蛋白2/HDC2抗体
Alias	HDC2; Early development regulatory protein 2; hPH2; early development regulator 2 (homolog of polyhomeotic 2); early development regulator 2 like; EDR2; MGC163502; mph2; PH2; PHC2; PHC2_HUMAN; polyhomeotic 2; polyhomeotic like 2; Polyhomeotic-like protein 2.
Research Area	Cell biology  Developmental biology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	91kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HDC2/PHC2: 651-750/858
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Subunit: Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2. Subcellular Location: Nucleus. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 1 FCS-type zinc finger. Contains 1 SAM (sterile alpha motif) domain. SWISS: Q8IXK0 Gene ID: 1912 Database links: Entrez Gene: 1912 Human Entrez Gene: 54383 Mouse Entrez Gene: 313038 Rat GenBank: NP_004418.2 Human Omim: 602979 Human SwissProt: Q8IXK0 Human SwissProt: Q9QWH1 Mouse Unigene: 524271 Human Unigene: 259103 Mouse Unigene: 2428 Rat

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