Product Name	SLC5A1
Chinese Name	钠-糖共转运载体1抗体
Alias	D22S675; High affinity sodium glucose cotransporter 1; GLT1; GLT-1; High affinity sodium glucose cotransporter; Human Na+/glucose cotransporter 1; Na(+)/glucose cotransporter 1; NAGT; SGLT 1; SGLT1; Sodium glucose cotransporter 1; Sodium/glucose cotransporter 1; Solute carrier family 5 (sodium/glucose cotransporter) member 1; Solute carrier family 5 member 1.
literatures	Specific References  (6)     |     SL1128R has been referenced in 6 publications. [IF=5.846] Gai-feng Hu. et al. SGLT1/2 as the potential biomarkers of renal damage under Apoe−/− and chronic stress via the BP neural network model and support vector machine. FRONT CARDIOVASC MED. 2022; 9: 948909  IF ;  Mouse.   PubMed:36035950 [IF=5.561] Yang Liu. et al. Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells. FOODS. 2022 Jan;11(23):3793  WB ;  Human.   PubMed:36496602 [IF=5.318] Yaoyao Liu. et al. Cinnamon free phenolic extract regulates glucose absorption in intestinal cells by inhibiting glucose transporters. FOOD BIOSCI. 2023 Apr;52:102405  WB ;  Human.   PubMed:10.1016/j.fbio.2023.102405 [IF=5.075] Qun Cheng. et al. Zearalenone Exposure Affects the Keap1–Nrf2 Signaling Patway and Glucose Nutrient Absorption Related Genes of Porcine Jejunal Epithelial Cells. TOXINS. 2022 Nov;14(11):793  WB ;  Pig.   PubMed:36422967 [IF=3.457] Wang N et al. Fibroblast growth factor 21 improves glucose homeostasis partially via down-regulation of Na+-d-glucose cotransporter SGLT1 in the small intestine.(2019) Biomedicine & Pharmacotherapy, 109, 1070–1077.  WB ;  Mouse.   PubMed:30551357 [IF=2.99] Chen, Zhaolin, et al. "Efficiency of transcellular transport and efflux of flavonoids with different glycosidic units from flavonoids of< i> Litsea coreana L in a MDCK epithelial cell monolayer model." European Journal of Pharmaceutical Sciences (2013).  WB ;  Dog.   PubMed:24365259
Research Area	Neurobiology  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	73kDa
Cellular localization	Extracellular matrix
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SGLT1: 401-500/665
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Function: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed mainly in intestine and kidney. Post-translational modifications: N-glycosylation is not necessary for the cotransporter function. DISEASE: Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. SWISS: Q8C3K6 Gene ID: 6523 Database links: Entrez Gene: 6523 Human Entrez Gene: 20537 Mouse Entrez Gene: 397113 Pig Entrez Gene: 25552 Rat Omim: 182380 Human SwissProt: P13866 Human SwissProt: Q8C3K6 Mouse SwissProt: P53790 Rat Unigene: 1964 Human Unigene: 25237 Mouse Unigene: 10224 Rat 葡萄糖的跨膜转运主要是通过SGLT1结合1 mol葡萄糖,2 mol的Na+,形成Na+-载体-葡萄糖复合物,顺Na+的浓度梯度进入细胞.不同物种的SGLT1具有较高的同源性.
Product Picture	Sample: Lane 1: Mouse Kidney Lysates Lane 2: Human 293T cell Lysates Lane 3: Human HepG2 cell Lysates Primary: Anti-SLC5A1 (SL1128R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 73kDa Observed band size: 70kDa Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SGLT1) Polyclonal Antibody, Unconjugated (SL1128R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min Block endogenous peroxidase by 3% Hydrogen peroxide for 30min Blocking buffer (normal goat serum) at 37℃ for 20 min Incubation: Anti-SGLT1 Polyclonal Antibody, Unconjugated(SL1128R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining

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