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Product Name Lymphotactin Chinese Name lymphocyteChemokine抗体 Alias Lptn; LTN; XCL1 C motif chemokine 1; SCM 1 alpha; ATAC; Chemokine C Motif Ligand 1; Cytokine SCM-1; LPTN; LTN; Lymphotactin; Lymphotaxin; SCM-1-alpha; SCM1; SCYC1; Small inducible cytokine C1; Small Inducible Cytokine Subfamily C Member 1; Small-inducible cytokine C1; XC chemokine ligand 1; Xcl1; XCL1_HUMAN. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 10kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Lymphotactin: 21-114/114 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Lymphotactin is a chemokine-like molecule produced selectively, if not exclusively, by activated CD8+ T cells (1). Lymphotactin is a C-type member of the chemokine superfamily, but retains only the 2nd and 4th of the four cysteine residues conserved in other chemokines (3,4). In normal tissues, lymphotactin is expressed at high levels in spleen, thymus, small intestine, and peripheral blood leukocytes, as well as at low levels in lung, prostate, and ovary (2). Lymphotactin is chemotactic for CD4+ and CD8+ T cells but not for monocytes, and induces a rise in intracellular calcium in peripheral blood lymphocytes (1). The specific receptor for lymphotactin is XCR1, a member of the G protein-coupled receptor family (5). The gene which encodes lymphotactin maps to human chromosome 1q23 (1,2).
Function:
Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
Subcellular Location:
Secreted.
Tissue Specificity:
Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Similarity:
Belongs to the intercrine gamma family.
SWISS:
P47992
Gene ID:
6375
Database links:Entrez Gene: 6375 Human
Omim: 600250 Human
SwissProt: P47992 Human
Unigene: 546295 Human
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