Product Name	GRAF
Chinese Name	Rho GTP酶激活蛋白26抗体
Alias	arhgap 26; ARHGAP26; FLJ42530; GRAF; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); KIAA0621; oligophrenin 1 like protein; Oligophrenin-1-like protein; oligophrenin1like protein; OPHN1L; OPHN1L1; RHG26_HUMAN; Rho GTPase activating protein 26; Rho GTPase activating protein26; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26.
Research Area	Tumour  Cardiovascular  Neurobiology  Signal transduction  Cytoskeleton  Extracellular matrix  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	92kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GRAF1: 1-100/814
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Cellular signaling by G-proteins is down-regulated by GTPase-activating proteins (GAPs), which increase the rate of GTP hydroylsis. The GTPase regulator associated with focal adhesion kinase (GRAF) has GAP activity toward Rho A and Cdc42, but not Rac1. GRAF is ubiquitously expressed with high levels in heart and brain. Expression of GRAF causes clearing of stress fibers and formation of long actin based filopodial-like extensions. Fusion of MLL with GRAF, MLL/GRAF, is included in a rare genetic subgroup of acute myeloid leukemia (AML) cases. Function: GTPase-activating protein for RHOA and CDC42. Subunit: Interacts with NYAP1, NYAP2 and MYO16 (By similarity). Binds to the C-terminus of PTK2/FAK1. Subcellular Location: Cell junction; focal adhesion. Cytoplasm; cytoskeleton. Colocalizes with actin stress fibers and cortical actin structures. DISEASE: Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient. Similarity: Contains 1 PH domain. Contains 1 Rho-GAP domain. Contains 1 SH3 domain. SWISS: Q9UNA1 Gene ID: 23092 Database links: Entrez Gene: 23092 Human Entrez Gene: 71302 Mouse Entrez Gene: 307459 Rat Omim: 605370 Human SwissProt: Q9UNA1 Human SwissProt: Q6ZQ82 Mouse Unigene: 654668 Human Unigene: 329396 Mouse Unigene: 214162 Rat
Product Picture	Sample: Cerebrum(Rat) Lysate at 40 ug Cerebrum(Mouse) Lysate at 40 ug Cerebellum(Rat) Lysate at 40 ug HepG2(Human) Cell Lysate at 30 ug Kidney(Rat) Lysate at 40 ug Kidney(Mouse) Lysate at 40 ug A549(Human) Cell Lysate at 30 ug A431(Human) Cell Lysate at 30 ug HL60(Human) Cell Lysate at 30 ug U937(Human) Cell Lysate at 30 ug Cerebellum(Mouse) Lysate at 40 ug Primary: Anti-GRAF (SL11248R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 36 kD Observed band size: 38 kD

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