Product Name	TMPRSS5
Chinese Name	跨膜丝氨酸蛋白酶5抗体
Alias	Spinesin; TMPRSS 5; TMPRSS-5; TMPRSS5; TMPS5_HUMAN; Transmembrane protease serine 5; Transmembrane protease, serine 5 (spinesin); Transmembrane protease, serine 5; MGC141886; MGC148044; OTTHUMP00000238209; OTTHUMP00000238210; OTTHUMP00000238211; OTTHUMP00000238212; OTTHUMP00000238213.
Research Area	Tumour  Cell biology  Neurobiology  Transmembrane protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	50kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TMPRSS5: 161-260/457
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. TMPRSS5 (transmembrane protease, serine 5), also known as spinesin, is a 457 amino acid single-pass type II membrane protein that is expressed specifically in brain and is thought to play a role in hearing. A member of the peptidase S1 family, TMPRSS5 contains one peptidase S1 domain and an SRCR domain, and is encoded by a gene that maps to human chromosome 11q23.2. Defects in the gene encoding TMPRSS5 are associated with deafness. Function: May play a role in hearing. Subcellular Location: Cell membrane. Post-translational modifications: Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord. DISEASE: Note=Defects in TMPRSS5 may be a cause of deafness. Similarity: Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain. Contains 1 SRCR domain. SWISS: Q9H3S3 Gene ID: 80975 Database links: Entrez Gene: 80975 Human Entrez Gene: 80893 Mouse Entrez Gene: 266681 Rat Omim: 606751 Human SwissProt: Q9H3S3 Human SwissProt: Q9ER04 Mouse Unigene: 46720 Human Unigene: 72799 Mouse

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