Product Name	RASSF5
Chinese Name	RASSF5抗体
Alias	ras association domain-containing family protein 5; RASF5_HUMAN; New ras effector 1; Regulator for cell adhesion and polarization enriched in lymphoid tissues; RAPL; Nore1; Rapl.
literatures	Specific References  (2)     |     SL11168R has been referenced in 2 publications. [IF=5.9] Yang, Rui, et al. "Rassf5 and Ndr kinases act in a novel pathway regulating neuronal polarity through Par3 phosphorylation." Journal of Cell Science (2014): jcs-146696.  Mouse.   PubMed:24928906 [IF=3.383] Guangduo Zhu et al. Exosomal miR-532–5p from bone marrow mesenchymal stem cells reduce intervertebral disc degeneration by targeting RASSF5. Exp Cell Res. 2020 Aug 15;393(2):112109.  WB ;  Rat.   PubMed:32464126
Research Area	Tumour  Cell biology  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	46kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RASSF5: 321-418/418
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. Subunit: Interacts directly with activated HRAS1; a RASSF5-STK4/MST1 complex probably associates with activated HRAS1. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS1. Isoform 2 interacts with activated RAP1A andITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4/MST1 autoactivation. Subcellular Location: Cytoplasm. Cytoplasm, cytoskeleton. unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A. Tissue Specificity: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors. Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Ras-associating domain. Contains 1 SARAH domain. SWISS: Q8WWW0 Gene ID: 83593 Database links: Entrez Gene: 83593 Human Entrez Gene: 54354 Mouse Entrez Gene: 54355 Rat Omim: 607020 Human SwissProt: Q8WWW0 Human SwissProt: Q5EBH1 Mouse SwissProt: O35141 Rat Unigene: 497579 Human Unigene: 248291 Mouse Unigene: 36106 Rat

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