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Product Name PCDHGA4 Chinese Name 原钙粘蛋白γA4抗体 Alias PCDHGA4; PCDHGA 4; PCDHGA-4; PCDH gamma A4; Protocadherin gamma A4; PCDG4_HUMAN. Research Area Signal transduction Cell adhesion molecule Cytoskeleton The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Horse, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 98kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PCDHGA4: 91-190/931 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHGA4 (Protocadherin gamma-A4) is a 931 amino acid that is one of 22 proteins encoded by the protocadherin gamma cluster. The protocadherein gamma cluster consists of three subfamilies (A, B and C) and PCDHGA4 is a member of the gamma subfamily A. PCDHGA4 is a type I transmembrane receptor containing six cadherin motifs and is expressed in the central nervous system where it localizes to synapses. Members of the gamma cluster of protocadherins are essential for neuronal survival. There are two isoforms of PCDHGA4 that are produced as a result of alternative splicing events.
Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Location:
Cell membrane; Single pass type I membrane protein
Similarity:
Contains 6 cadherin domains.
SWISS:
Q9Y5G9
Gene ID:
56111
Database links:
Entrez Gene: 56111 Human
Entrez Gene: 93712 Mouse
UniProtKB/Swiss-Prot: Q9Y5G9.1
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