Product Name	Rho B
Chinese Name	RhoB蛋白抗体
Alias	Rh -related GTP binding protein RhoB; Rh -related GTP binding protein RhoC; RHOH6; Transforming protein RhoA; AA017882 antibody Aplysia ras related homolog 9 (RhoC); ARH9; ARHA; ARHB; ARHC; H6; MST081; MSTP08; Oncogene RHO H9; rhoC GTPase; Ras homolog 9 (RhoC); Ras homolog gene family, member A; Ras homolog gene family, member B; Ras homolog gene family, member C; Rho related GTP binding protein RhoC; RHO12; RHOB; RHOC; RHOH9; RP11-426L16.4; Small GTP binding protein RhoC; H9; Rho related GTP binding protein RhoB; ARH12; ARH6; H12.RHOB_HUMAN
literatures	Specific References  (1)     |     SL11142R has been referenced in 1 publications. [IF=2.1] Jun Li. et al. WJ‑MSCs intervention may relieve intrauterine adhesions in female rats via TGF‑β1‑mediated Rho/ROCK signaling inhibition. Mol Med Rep. 2021 Jan;23(1):1-1  IHC ;  Rat.   PubMed:33179074
Research Area	Cell biology  Signal transduction  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	The nucleus cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Rho B: 101-196/196
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The Rho proteins interact directly with protein kinases which are likely to serve as downstream effector targets of the activated GTPase. The Rho family of GTPases are involved in the regulation of the actin skeleton. Activation of Rho to the GTP bound state promotes formation of stress fibers and is required for the formation and maintenance of focal adhesions. Pathways stimulated by cytokines, hormones and various forms of stress utilize p21 proteins of the Rho family. Possible mediators for these responses include protein kinase such as p120PKN, and p150 ROKa/Rho-A kinase, myosin light chain (MLC) phosphatase and PIP 5-kinase. Function: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells. Subunit: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13. Subcellular Location: Rho A: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm; cytoskeleton. Rho B: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Rho C: Cell membrane; Lipid-anchor; Cytoplasmic side. Post-translational modifications: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome. Similarity: Belongs to the small GTPase superfamily. Rho family. SWISS: P62745 Gene ID: 388 Database links: Entrez Gene: 395734 Chicken Entrez Gene: 515118 Cow Entrez Gene: 388 Human Entrez Gene: 11852 Mouse Entrez Gene: 100144503 Pig Entrez Gene: 64373 Rat Omim: 165370 Human SwissProt: Q3ZBW5 Cow SwissProt: P62745 Human SwissProt: P62746 Mouse SwissProt: P62747 Rat Unigene: 502876 Human Unigene: 687 Mouse Unigene: 2042 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human pancreatic cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Rho B) Polyclonal Antibody, Unconjugated (SL11142R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining. Paraformaldehyde-fixed, paraffin embedded (Human pancreatic cancer); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Rho B) Polyclonal Antibody, Unconjugated (SL11142R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructions and DAB staining.

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