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Product Name PCDH17 Chinese Name 原钙粘附蛋白17抗体 Alias PCDH68; C030033F14Rik; Gm78; PCD17_HUMAN; PCDH17; PCDH-17; PCDH 17; PCH68; Protocadherin 17; Protocadherin 68; Protocadherin-17; Protocadherin-68. Research Area Neurobiology Signal transduction Cell adhesion molecule Cytoskeleton The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 124kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PCDH17: 31-130/1159 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH17 is a 1,159 amino acid single-pass type I membrane protein that contains six cadherin domains. Expressed as multiple alternatively spliced isoforms, PCDH17 is thought to function as a calcium-dependent cell adhesion protein that may play a role in establishing cell-cell connections within brain tissue. The gene encoding PCDH17 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
Function:
Potential calcium-dependent cell-adhesion protein.
Subcellular Location:
Cell membrane.
Similarity:
Contains 6 cadherin domains.
SWISS:
O14917
Gene ID:
27253
Database links:Entrez Gene: 27253 Human
Omim: 611760 Human
SwissProt: O14917 Human
Unigene: 106511 Human
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